ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
J. Clin. Invest. Kensuke Noma, et al. 118:1632 doi:10.1172/JCI29226 [
Go to this article.]
Figure 1Decreased neointima formation after carotid artery ligation in
Rock1+/– mice.
(
A) Representative cross sections of contralateral unligated and ligated carotid arteries in WT,
Rock1+/–, and
Rock2+/– mice at 28 days after ligation. Scale bar: 100 μm. (
B) Representative immunohistochemical analysis of ROCK expression and activity in carotid arteries from WT and
Rock1+/– mice at 14 days after ligation. Vessels were stained with nonspecific antibody (IgG), and antibodies were directed at total MBS (tMBS), phosphorylated MBS (pMBS), ROCK1, and ROCK2. The I and M indicate the intima and media, respectively. Scale bar: 50 μm.
