Inherited human cPLA_2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction
J. Clin. Invest. David H. Adler, et al. 118:2121 doi:10.1172/JCI30473 [Go to this article.]

Figure 5
Platelet aggregation and dense granule release. (A) Representative measurements of platelet aggregation and simultaneous ATP release. Left panel shows aggregation (blue) and ATP release (black) in platelets from a normal control in response to ADP (10 μM). Middle panel shows aggregation (blue and red, performed in duplicate) and ATP release (black and green, in duplicate) in platelets from the proband in response to ADP (10 μM). Right panel shows aggregation (blue and red, in duplicate) and ATP release (black and green, in duplicate) in platelets from the proband in response to AA (500 μM). (B) Optical platelet aggregation in PRP in response to ADP (5 μM) or collagen (2 μg/ml) and ATP release as a measure of platelet degranulation recorded simultaneously during platelet aggregation. Each point represents 1 measurement (different days for the patient and different control volunteers); horizontal bars represent mean.