p21Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice
J. Clin. Invest. Michelle Olive, et al. 118:2050 doi:10.1172/JCI31244 [
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Figure 3Impaired wound healing in
p21–/– mice in vivo.
(
A) Increased cell proliferation was observed in
p21–/– mice (blue bars) compared with
p21+/+ mice (yellow bars) at the 1- and 2-week time points after arterial injury (
n = 8; *
P < 0.05 versus
p21+/+ at same time point) (
B) Increased intima/media area ratio in
p21–/– arteries (blue bars) compared with
p21+/+ arteries (yellow bars) following wire injury (
n = 8; *
P < 0.05 versus
p21+/+ 1 wk, ***
P < 0.001 versus
p21+/+ 2 wk). (
C) Representative cross-sections of
p21+/+ (left) and
p21–/– (right) arteries stained with H&E, elastin (black), and BrdU 1 and 2 weeks after injury. Arrows indicate the internal elastic lamina. Scale bars: 40 μm.
