p21Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice
J. Clin. Invest. Michelle Olive, et al. 118:2050 doi:10.1172/JCI31244 [
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Figure 4p21–/– mice develop acute arterial inflammation after vascular injury.
Accumulation of (
A) macrophages, (
B) neutrophils, and (
C) T lymphocytes in the femoral artery (neointima, media, and adventitia) of
p21+/+ (yellow bars) and
p21–/– (blue bars) at 1 and 2 weeks after vascular injury (
n = 8; *
P < 0.05 and **
P < 0.01 versus
p21+/+ at same time point). (
D) Representative photomicrographs of cross-sections of
p21+/+ (left) and
p21–/– (right) arteries immunostained for macrophages, neutrophils, and T lymphocytes (brown). Arrows indicate the internal elastic lamina. Scale bars: 20 μm.
