Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [
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Figure 2Efficacy of the mFVIIa or the mFVII zymogen transgene in HB mice. (
A) Plasma mFVIIa levels (mFVII levels were measured by a separate antigen ELISA resulting in ~1,700 ng/ml), (
B) PT, (
C) aPTT, and (
D) TAT levels in littermate HB (
n = 21), WT (
n = 21), HB-mFVII (
n = 4), HB–low-mFVIIa (
n = 10), and HB–high-mFVIIa (
n = 7) mice. *
P < 0.05 versus HB. Values are mean ± 1 SD.
