Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [
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Figure 4Expression of high mFVIIa levels is associated with increased mortality after crossing the founder C57BL/6–SJL mice into C57BL/6 pure strain background. Kaplan-Meier survival plot of transgenic mFVIIa mice with low or high levels of transgene expression compared with WT littermates. Curves for high mFVIIa expressers exclude animals dying within 72 h of birth. Squares, WT (
n = 10); filled circles, low-mFVIIa N1–N4 (
n = 25); triangles, high-mFVIIa F0 (
n = 6); diamonds, high-mFVIIa N1 (
n = 17); open circles, high-mFVIIa N2 (
n = 11). *
P < 0.05 versus WT.
