Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [
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Figure 5Histological findings in lungs and hearts of high-mFVIIa transgenic mice compared with WT littermates. Intimal/smooth muscle proliferation was observed in the pulmonary veins (
B and
C) as well as fibrin deposition in the pulmonary bed (
E and
F) of mFVIIa transgenic mice, but neither was seen in WT mice (
A and
D). Thrombi were observed in the coronary artery (
I and
M) and ventricles (
H and
L) as well as inflammatory infiltrates in the myocardium (
J and
N) of mFVIIa transgenic mice, but none were observed in WT mice (
G and
K). Original magnification, ×20 (
H and
L); ×40 (
G and
K); ×100 (
D,
E,
I, and
M); ×200 (
A–
C,
F,
J, and
N).
