Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [
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Figure 6Hemostatic differences in high-mFVIIa transgenic mice. (
A) mFVIIa antigen; (
B) PT measurements using hFX-deficient plasma; (
C) TAT levels; and (
D) Kaplan-Meier survival plot of high-mFVIIa transgenic mice in a background between ~3% and 100% mFX. (
A–
C)
n = 3 (~3% mFX and high-mFVIIa ~3% mFX), 4 (high-mFVIIa), 6 (WT), 8 (50% mFX), 12 (high-mFVIIa 50% mFX). (
D) Open squares, WT (
n = 10); filled circles, high-mFVIIa F0 (
n = 3); stars, high-mFVIIa F2 ~3% mFX (
n = 8); diamonds, high-mFVIIa F2 50% mFX (
n = 17); crossed-out squares, high-mFVIIa F1 100% mFX (
n = 11); open circles, high-mFVIIa F2 100% mFX (
n = 7). *
P < 0.05 versus WT. Values are mean ± 1 SD.
