Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome
J. Clin. Invest. Michael Brunner, et al. 118:2246 doi:10.1172/JCI33578 [
Go to this article.]
Figure 5Sudden death and spontaneous arrhythmias. (
A) Kaplan-Meier survival curve of 51 LMC, 26 LQT1, and 34 LQT2 rabbits. (
B) Sample ventricular extrasystoles (bigeminy) with R-on-T phenomenon in the LQT2 founder rabbit during ECG (leads I, II, III) recording with midazolam sedation. Asterisks denote ventricular extrasystoles. This rabbit died suddenly approximately 2 weeks after this recording. (
C) Telemetric recording of a polymorphic VT leading to the death of a LQT2 rabbit. The torsade is initiated by repetitive short-long-short sequences due to ventricular extrasystoles. (
D) Spontaneous polymorphic tachycardia in a ketamine/xylazine-anesthetized rabbit. Top panel shows ECG lead II. Bottom panel shows simultaneous arterial pressure recorded from the ear artery.
