The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
J. Clin. Invest. Godwin Nchinda, et al. 118:1427 doi:10.1172/JCI34224 [Go to this article.]

Figure 5
A single, low-dose injection of DC-targeted DNA vaccine provides protective immunity to airway challenge with vaccinia gag virus. C×B6 F1 mice received graded doses of scDEC and scControl HIV gag DNA vaccine, and after 3 months, they were challenged i.n. with vaccinia gag virus. (A) Illustrative data of average weight (left panels) and mean ± SD lung virus titers (right panels) after challenge. (B) Summary of data from a total of 4 different experiments (5 mice per group), 2 each in BALB/c and BALB/c × C57Bl/6 F1 mice (*P < 0.05).