A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy
J. Clin. Invest. Anja Fritsch, et al. 118:1669 doi:10.1172/JCI34292 [Go to this article.]

Figure 4
Col7a1^flNeo/flNeo mice exhibit growth retardation as a result of malnutrition. Although normal at birth, Col7a1^flNeo/flNeo mice grew slower than their Col7a1^WT/WT or Col7a1^flNeo/WT littermates. (A) Mean ± SD weight of Col7a1^flNeo/flNeo (n = 25 [14–20 d]; 13 [40–60 d]) compared with control littermates (n = 50). *P < 0.001, Student’s t test. (B) H&E staining of tongue of 17-day-old mice, with arrows highlighting hemorrhagic blisters. Scale bar: 50 μm.